This year’s keynote speaker is Michael Pinsky, Professor of Critical Care Medicine with secondary appointments in Cardiovascular Diseases, Clinical & Translational Science, Anesthesiology, and Bioengineering at the University of Pittsburgh, Pennsylvania, USA. He has published >230 peer-reviewed papers, >210 chapters, and 24 books. His CV is a book in and by itself. He is Editor-in-Chief of eMedicine’s Critical Care Medicine and is on numerous editorial boards and international programs. He received numerous awards from prestigious universities. He is a member of the ACGME Review Board for Pulmonary & CCM. His research interests are heart-lung interactions, cardiovascular insufficiency, hemodynamic monitoring, sepsis, mechanical ventilation, and health services research and quality of life after critical illness. He will use his superb lecture skills to give his lecture, Applied cardiovascular physiology in theatre: Measuring the cardiovascular effects of propofol anesthesia.
Michael Avram received his B.S. in Chemistry from Michigan State University and his Ph.D. in Pharmacology from Loyola University of Chicago. He joined the faculty of the Department of Anesthesiology at Northwestern University Feinberg School of Medicine, where he is a tenured Associate Professor of Anesthesiology and Director of the Mary Beth Donnelley Clinical Pharmacology Core Facility. He is a diplomat of the American Board of Clinical Pharmacology, an Executive Editor of Anesthesiology, and a member of the Editorial Board of Clinical Pharmacology & Therapeutics. He has published > 130 peer-reviewed papers. He developed PK models that describe the early kinetics of rapidly acting IV administered drugs. These models help describe interindividual variability in response to these agents, which often have low clinical margins of safety. We are looking forward to his lecture “Front-end kinetics: the first two min after injecting propofol”.
Gerhard Schneider is Professor and Chair of the Department of Anaesthesiology at the Technische Universität Münich. He is past chairman of the ESA Scientific Subcommittee on Neurosciences. His research focuses on mechanisms of anesthesia-induced unconsciousness, detection, prevention and treatment of awareness, recall, and their sequels, and monitoring of anesthetic effects on the brain. Prof. Schneider will tell us how we should navigate towards an appropriate depth of anesthesia: ”The Future of depth of anesthesia monitoring: from probabilistic to mechanism-based monitoring”.
Andrew Kofke is Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania, Department of Anesthesiology and Critical Care, Perelman School of Medicine (2001) and Professor of Neurology, Department of Neurology, Perelman School of Medicine (2014). He is past president of the Society for Neuroscience in Anesthesiology and Critical Care. He has published > 100 manuscripts, books, and book chapters. He studied Medicine at the University of Pittsburgh. During his residency and fellowship at the Massachusetts General Hospital, Boston, 1979-1983, he wrote the chapter “Closed circuit anesthesia” in “Clinical Anesthesia Procedures of the Massachusetts General Hospital”, 3rd Edition. His work has included neurotoxicity of opioids and more recently of inhaled agents. His NAVAt lecture will focus on the latter: “Neurotoxicity of inhaled agents after prolonged administration.”
Robert Pearce is Professor and R.M. Waters Distinguished Chair of Anesthesiology, University of Wisconsin, Madison, Wisconsin, USA. He has been a member of the Scientific Advisory Board of the Association of University Anesthesiologists, Associate Editor of Anesthesiology, and a member of the Committee on Research of the ASA. Research in the Pearce laboratory is focused on the mechanisms by which general anesthetics alter brain function. They are particularly interested in understanding how modulation of GABA receptors impairs memory – a fundamental endpoint of anesthesia. They utilize expressed recombinant receptors and hippocampal brain slices to investigate the roles of specific subunit combinations and cell types in the control of learning and memory. In a sense, the Pearce lab is also working on the ultimate closed circuit administration methods, intravenous sevoflurane, which he will tell us all about in his lecture “As closed as it gets: intravenous sevoflurane”.
Joseph Fisher is Professor at the Department of Anesthesia and Pain Management, Toronto General Hospital. His group has developed several innovative approaches regarding the delivery of inhaled agents. He has supervised approximately 25 graduate students; has authored or co-authored about 145 peer-reviewed publications; has 30 issued patents, with about a dozen patents pending. At NAVAt II (2014), he introduced us to the concept of isocapnic hyperventilation. At this NAVAt V lustrum edition, Prof. Fisher will explain us the technical aspects of a novel system that allows one to deliver inhaled agents with any ventilator and that makes agent usage largely independent of fresh gas flow by combining an in-circle vaporizer with an agent reflector. Details to be heard at his lecture “The RIVAL™ ”, digital in-line vaporizer plus anesthetic shield: maximum control and maximum efficiency of anesthetic delivery.
-Bio to be published-
University Health Network - Toronto General Hospital
cardiovascular anesthesia, hyperbaric medicine, perioperative patient management
Andres Meiser is Senior Doctor in the Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University, University Medical Centre, Homburg/Saar, Germany. He has considerable experience with the use of the ANACONDA™ system to deliver inhaled agents in the ICU, which he described in several peer reviewed manuscripts. We look forward to learn from him about the technical aspects of the ANACONDA™ system used to deliver inhaled agent outside the operating room.
Hagen Bomberg is a resident in the Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University, University Medical Centre, Homburg/Saar, Germany. As the first author of the initial reports on the MIRUS™ system, he will share with us his hands-on experience with the MIRUS™ system. The system can be used to deliver isoflurane, sevoflurane, and desflurane with any ventilator.Professor Berry will examine how inhaled anesthetic agents can be recycled.
Andre De Wolf
Andre De Wolf has been a member of the team of liver transplant pioneer Dr. Thomas Starzl in Pittsburgh between 1988 and 1996, and published extensively on aspects of liver transplantation. He currently works in Chicago. His other major interest involves the kinetics of inhaled anesthetics and carrier gases at reduced fresh gas flows. His first lecture will address the benefits of the use of reduced fresh gas flows and effect of rebreathing on the concentrations of carrier gases and inhaled anesthetics. This helps us understand the rationale behind automating low flow and closed circuit anesthesia. His second lecture will address safety issues of automated low flow anesthesia and PKPD visual display systems as well as the future role of the anesthesiologist.
Jan Hendrickx graduated from the University in Pittsburgh, 1996, and has been studying quantitative aspects of low flow and closed circuit anesthesia ever since. His research at the OLV Hospital in Aalst resulted in a thesis “Pharmacokinetics of Inhaled Anesthetics And Carrier gases” in 2004. During a two year sabbatical (2004-2006) at Stanford with Steven Shafer (Editor in Chief, Anesthesia and Analgesia) he extended his expertise to pharmacokinetic and pharmacodynamic modeling of intravenous and inhaled anesthetics. In his first lecture he will address the contemporary definition of anesthetics depth, key to the remainder of the morning session. Later, he examines the broader impact of automated low flow anesthesia (agent and CO2 absorbent usage, environmental implications, costs) and provide a glimpse of how future anesthesia stations might look. Effective January 1 2013, he has been appointed chair of the ESA committee on Anesthesia Monitoring, Equipment and Computers.
Philip Peyton is, without exaggeration, the world’s expert on lung uptake and distribution of inhaled anesthetic vapors and carrier gases. He is Associate Professor at Austin Hospital, Melbourne. His PhD thesis published in 2012, “The effects of ventilation-perfusion scatter on gas exchange during N2O anaesthesia”, won the Dean’s Award for Excellence. Contrary to popular belief, it concluded that the pharmacokinetic advantages of N2O have been largely underestimated, and should not be ignored in assessing the place of N2O in future clinical practice.
Yet Dr. Peyton also is a member of the ENIGMA (Elimination of N2O in Gas Mixtures during Anesthesia) trial group. The paradox between the findings in his thesis and those in the ENIGMA ensure Dr. Peyton will provide the attendee in his first lecture with a uniquely balanced and new perspective on the use of N2O that has important implications for automated low flow and visual display systems. In his second lecture, he will present the effects of the introduction of automated low flow anesthesia in Australia.
Michel MRF Struys
Michel MRF Struys is Professor and Chair at the Department of Anesthesiology, University of Groningen and University Medical Center Groningen. His research group is one of the world leading groups in anesthetic pharmacology, including PK/PD modelling, drug interaction research and drug administration systems such as TCI and closed-loop. He is also affiliated as a Professor in Anesthesia to the Ghent University, Belgium. He is an editor of the British Journal of Anaesthesia and a former associated editor for Anesthesiology. He is one of the Past Presidents of the International Society of Anesthetic Pharmacology, Board Member of EuroSIVA and Committee member of the committee on Pharmacology of the ESA. His lecture will address the scientific background, clinical application, and clinical impact of PK/PD visual display systems (SmartPilot and Navigator).
Patrick Wouters is Professor and Chair of the Department of Anesthesia and Perioperative Medicine and Professor of Clinical Physiology at Ghent University, Belgium. He has published extensively on right ventricular function. He has chaired the ESA Scientific Subcommittee on Clinical and Experimental Circulation and the Subcommittee of the European Association of Cardiothoracic Anaesthesiologists on Echocardiography. He will share some of his expertise as chair at NAVAt V.
Geert Vandenbroucke, Chair of the Department of Anesthesiology, CCM, and Pain Medicine at the OLV hospital, has been unrelenting in his support for NAVAt and will be hosting NAVAt again.
Jan Verbeke will co-chair NAVAt V. He graduated from Ghent University, Belgium, and is board certified in Anesthesiology and CCM. He was actively involved in the development of CCM in Belgium. He is director of the OLV CCM department. He is a former member of the Belgian Accreditation Board of Anesthesiology and CCM. He is secretary of the Belgian Professional Society of Physician-Specialists in CCM. He has a special interest in ventilator and nutritional aspects of CCM.
Koen De Decker
Koen De Decker graduated from Antwerp University, Belgium, and is board certified in Anesthesiology and CCM. He is co-director of the OLV CCM department. He is member of the Belgian CCM accreditation council, member of the scientific committee of the Belgian Society of Intensive Care Medicine (SIZ), and director of the OLV CCM residency program. He has a special interest in cardiovascular anesthesia and intensive care medicine, with special emphasis on the management of end-stage heart disease (mechanical support, heart transplantation). He will co-chair NAVAt V.